Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis.

@article{Lee2010IdentificationOU,
  title={Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis.},
  author={Joon No Lee and Hyeonwoo Kim and Hongbing Yao and Yan Chen and Kayson Weng and Jin Ye},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 50},
  pages={21424-9}
}
Fatty acids (FAs) are essential for cell survival, yet their overaccumulation causes lipotoxicity. To prevent lipotoxicity, cells store excess FAs as triglycerides (TGs). In cultured cells TG synthesis is activated by excess unsaturated but not saturated FAs. Here, we identify Ubxd8 as a sensor for unsaturated FAs and regulator of TG synthesis. In cultured cells depleted of FAs, Ubxd8 inhibits TG synthesis by blocking conversion of diacylglycerols (DAGs) to TGs. Excess unsaturated but not… CONTINUE READING