Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.

  title={Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.},
  author={Osman Cen and Magdalena M. Gorska and Susan J Stafford and Sanjiv Sur and Rafeul Alam},
  journal={The Journal of biological chemistry},
  volume={278 10},
Lyn, an Src-type tyrosine kinase, is associated with the interleukin (IL)-5 receptor in eosinophils. The mechanism of its activation is unknown. Through yeast two-hybrid screening we have cloned and characterized a new signaling molecule, Unc119, that associates with IL-5Ralpha and Src family tyrosine kinases. Unc119 induces the catalytic activity of these kinases through interaction with Src homology 2 and 3 domains. IL-5 stimulation of eosinophils increases Unc119 association with Lyn and… CONTINUE READING

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