Identification of Tyrosyl-DNA Phosphodiesterase as a Novel DNA Damage Repair Enzyme in Arabidopsis 1 [ C ] [ W ] [ OA ]

@inproceedings{Lee2010IdentificationOT,
  title={Identification of Tyrosyl-DNA Phosphodiesterase as a Novel DNA Damage Repair Enzyme in Arabidopsis 1 [ C ] [ W ] [ OA ]},
  author={So-Young Lee and Hoyeun Kim and Hyun-Ju Hwang and Young-Min Jeong and Sang Hyeon Na and Je-Chang Woo and Sang-Gu Kim},
  year={2010}
}
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a key enzyme that hydrolyzes the phosphodiester bond between tyrosine of topoisomerase and 3#-phosphate of DNA and repairs topoisomerase-mediated DNA damage during chromosome metabolism. However, functional Tdp1 has only been described in yeast and human to date. In human, mutations of the Tdp1 gene are involved in… CONTINUE READING