Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids Biosynthesis

@inproceedings{Viner2012IdentificationOT,
  title={Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids Biosynthesis},
  author={Ram Viner and David Chetrit and Marcelo Ehrlich and Gil Segal},
  booktitle={PLoS pathogens},
  year={2012}
}
The intracellular pathogen Legionella pneumophila translocates a large number of effector proteins into host cells via the Icm/Dot type-IVB secretion system. Some of these effectors were shown to cause lethal effect on yeast growth. Here we characterized one such effector (LecE) and identified yeast suppressors that reduced its lethal effect. The LecE lethal effect was found to be suppressed by the over expression of the yeast protein Dgk1 a diacylglycerol (DAG) kinase enzyme and by a deletion… CONTINUE READING

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