Identification of Tumor Suppressors and Oncogenes from Genomic and Epigenetic Features in Ovarian Cancer

@inproceedings{Wrzeszczynski2011IdentificationOT,
  title={Identification of Tumor Suppressors and Oncogenes from Genomic and Epigenetic Features in Ovarian Cancer},
  author={Kazimierz O. Wrzeszczynski and Vinay Varadan and James Byrnes and Elena Lum and Sitharthan Kamalakaran and Douglas A. Levine and Nevenka Dimitrova and Michael Q Zhang and Robert Lucito},
  booktitle={PloS one},
  year={2011}
}
The identification of genetic and epigenetic alterations from primary tumor cells has become a common method to identify genes critical to the development and progression of cancer. We seek to identify those genetic and epigenetic aberrations that have the most impact on gene function within the tumor. First, we perform a bioinformatic analysis of copy number variation (CNV) and DNA methylation covering the genetic landscape of ovarian cancer tumor cells. We separately examined CNV and DNA… CONTINUE READING
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