Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype

@inproceedings{OhmuraKakutani2014IdentificationOT,
  title={Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype},
  author={Hitomi Ohmura-Kakutani and Kosuke Akiyama and Nako Maishi and Noritaka Ohga and Yasuhiro Hida and Taisuke Kawamoto and Junichiro Iida and Masanobu Shindoh and Kunihiko Tsuchiya and Nobuo Shinohara and Kyoko Hida},
  booktitle={PloS one},
  year={2014}
}
Tumor blood vessels play an important role in tumor progression and metastasis. It has been reported that tumor endothelial cells (TECs) exhibit highly angiogenic phenotypes compared with those of normal endothelial cells (NECs). TECs show higher proliferative and migratory abilities than those NECs, together with upregulation of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2). Furthermore, compared with NECs, stem cell markers such as Sca-1, CD90, and multidrug… CONTINUE READING