Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.

@article{Obermeier1993IdentificationOT,
  title={Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.},
  author={Axel Obermeier and Reiner Lammers and K H Wiesm{\"u}ller and Gunther Jung and Joseph Schlessinger and Axel Ullrich},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 31},
  pages={22963-6}
}
Phosphotyrosine-containing synthetic peptides were used to identify the binding sites for cellular polypeptides involved in nerve growth factor receptor/Trk-mediated signal transduction. In vitro association of SHC and the p85 subunit of phosphatidylinositol 3'-kinase with the Trk tyrosine kinase was prevented only by phosphorylated Y-490- and Y-751… CONTINUE READING