Identification of Three Interferon-Inducible Cellular Enzymes That Inhibit the Replication of Hepatitis C Virus

@article{Jiang2007IdentificationOT,
  title={Identification of Three Interferon-Inducible Cellular Enzymes That Inhibit the Replication of Hepatitis C Virus},
  author={Dong Jiang and Haitao Guo and C. Xu and J. Chang and B. Gu and L. Wang and T. Block and J. Guo},
  journal={Journal of Virology},
  year={2007},
  volume={82},
  pages={1665 - 1678}
}
  • Dong Jiang, Haitao Guo, +5 authors J. Guo
  • Published 2007
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT Hepatitis C virus (HCV) infection is a common cause of chronic hepatitis and is currently treated with alpha interferon (IFN-α)-based therapies. However, the underlying mechanism of IFN-α therapy remains to be elucidated. To identify the cellular proteins that mediate the antiviral effects of IFN-α, we created a HEK293-based cell culture system to inducibly express individual interferon-stimulated genes (ISGs) and determined their antiviral effects against HCV. By screening 29 ISGs… CONTINUE READING
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