Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening

@article{Bettiol2009IdentificationOT,
  title={Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening},
  author={Esther Bettiol and Marie Samanovic and Andrew S Murkin and Jayne Raper and Frederick S Buckner and Ana Rodr{\'i}guez},
  journal={PLoS Neglected Tropical Diseases},
  year={2009},
  volume={3},
  pages={e332 - 285}
}
The development of new drugs against Chagas disease is a priority since the currently available medicines have toxic effects, partial efficacy and are targeted against the acute phase of disease. At present, there is no drug to treat the chronic stage. In this study, we have optimized a whole cell-based assay for high throughput screening of compounds that inhibit infection of mammalian cells by Trypanosoma cruzi trypomastigotes. A 2000-compound chemical library was screened using a recombinant… CONTINUE READING
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