Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes

@inproceedings{Silanes2014IdentificationOT,
  title={Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes},
  author={Isabel L{\'o}pez de Silanes and Osvaldo Gra{\~n}a and Maria Luigia De Bonis and Orlando E. Soberanis Dom{\'i}nguez and David G. Pisano and Maria A Blasco},
  booktitle={Nature communications},
  year={2014}
}
Telomeric RNAs (TERRAs) are UUAGGG repeat-containing RNAs that are transcribed from the subtelomere towards the telomere. The precise genomic origin of TERRA has remained elusive. Using a whole-genome RNA-sequencing approach, we identify novel mouse transcripts arising mainly from the subtelomere of chromosome 18, and to a lesser extend chromosome 9, that resemble TERRA in several key aspects. Those transcripts contain UUAGGG-repeats and are heterogeneous in size, fluctuate in abundance in a… CONTINUE READING

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