Identification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells.

@article{Yang2005IdentificationOT,
  title={Identification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells.},
  author={M Yang and Jau-Ling Suen and Shiao-Lan Li and Bor-Luen Chiang},
  journal={Immunology},
  year={2005},
  volume={115 2},
  pages={279-86}
}
Systemic lupus erythematosus (SLE) is characterized by the existence of a heterogeneous group of autoantibodies such as anti-DNA, chromatin, histone, and ribonucleoprotein antibodies (Abs). Although the B-cell antigenic determinants have been well characterized, very limited data about the T-cell epitopes of self-antigen (Ag) have been reported. In the present study, we analysed auto-T-cell epitopes using bone marrow-derived dendritic cells (BM-DCs) pulsed with murine U1A (mU1A) protein capable… CONTINUE READING