Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malaria.

Abstract

AMA-1 of Plasmodium falciparum is a promising candidate antigen in malaria vaccine development. In this study, we have mapped the immunodominant T-cell determinants in this antigen by using synthetic peptides. From the amphipathic scores, 17 putative T-cell determinants were identified. Nine of the 17 peptides complementary to the putative T-cell… (More)

Topics

Cite this paper

@article{Lal1996IdentificationOT, title={Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malaria.}, author={Altaf A. Lal and Mark Hughes and Dafne A. Oliveira and Cory O Nelson and Peter B. Bloland and Aggrey J Oloo and William Hawley and Allen Hightower and Bernard L. Nahlen and Venkatachalam Udhayakumar}, journal={Infection and immunity}, year={1996}, volume={64 3}, pages={1054-9} }