Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

  title={Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites},
  author={Filip K. Swirski and Matthias Nahrendorf and Martin Etzrodt and Moritz Wildgruber and Virna Cortez-Retamozo and Peter R. Panizzi and Jose-Luiz Figueiredo and Rainer H. Kohler and Aleksey Chudnovskiy and Peter Waterman and Elena Aikawa and Thorsten R. Mempel and Peter Libby and Ralph Weissleder and Mikael J. Pittet},
  pages={612 - 616}
Monitoring Monocyte Reservoirs Monocytes are cells of the immune system that are recruited to sites of tissue injury and inflammation where they help to resolve the infection and are important for tissue repair. The bone marrow and blood are believed to be the primary reservoirs from which monocytes are mobilized after injury. Swirski et al. (p. 612; see the Perspective by Jia and Pamer) now demonstrate that the spleen also serves as a critical reservoir of monocytes that are recruited during… 

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