Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat

@inproceedings{Bradesi2015IdentificationOS,
  title={Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat},
  author={Sylvie Bradesi and Iordanes Karagiannides and Kyriaki Bakirtzi and Swapna Joshi and Georgios Koukos and Dimitrios C. Iliopoulos and Charalabos Pothoulakis and Emeran A. Mayer and Chang-qing Gao},
  booktitle={PloS one},
  year={2015}
}
INTRODUCTION Animal studies have shown that stress could induce epigenetic and transcriptomic alterations essential in determining the balance between adaptive or maladaptive responses to stress. We tested the hypothesis that chronic stress in rats deregulates coding and non-coding gene expression in the spinal cord, which may underline neuroinflammation and nociceptive changes previously observed in this model. METHODS Male Wistar rats were exposed to daily stress or handled, for 10 days. At… CONTINUE READING
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