Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

@inproceedings{Monfort2015IdentificationOS,
  title={Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells},
  author={Asun Monfort and Giulio Di Minin and Andreas Postlmayr and Remo Freimann and Fabiana Arieti and St{\'e}phane Thore and Anton Wutz},
  booktitle={Cell reports},
  year={2015}
}
In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was able to identify several candidate… CONTINUE READING
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