Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen

  title={Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen},
  author={Anthony Arnoldo and Jasna Curak and Saranya Kittanakom and Igor Chevelev and Vincent Tsung-yeh Lee and Mehdi Sahebol-Amri and Becky Koscik and Lana Ljuma and Peter J. Roy and Antonio Bedalov and Guri Giaever and Corey Nislow and Rod A. Merrill and Stephen Lory and Igor Stagljar},
  journal={PLoS Genetics},
  pages={36 - 45}
Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide. Because resistance of Pseudomonas aeruginosa to antibiotics is increasing, new inhibitors of pharmacologically validated targets of this bacterium are needed. Here we demonstrate that a cell-based yeast phenotypic assay, combined with a large-scale inhibitor screen, identified small molecule… CONTINUE READING
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