Identification of Small Molecule Inhibitors of Pre-mRNA Splicing*

Abstract

Eukaryotic pre-mRNA splicing is an essential step in gene expression for all genes that contain introns. In contrast to transcription and translation, few well characterized chemical inhibitors are available with which to dissect the splicing process, particularly in cells. Therefore, the identification of specific small molecules that either inhibit or… (More)
DOI: 10.1074/jbc.M114.590976

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