Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

@article{Nakao1997IdentificationOS,
  title={Identification of Smad7, a TGF$\beta$-inducible antagonist of TGF-$\beta$ signalling},
  author={A. Nakao and M. Afrakhte and A. Morn and T. Nakayama and J. Christian and R. Heuchel and S. Itoh and M. Kawabata and N. Heldin and C. Heldin and P. Dijke},
  journal={Nature},
  year={1997},
  volume={389},
  pages={631-635}
}
TGF-β signals from the membrane to the nucleus through serine/threonine kinase receptors and their downstream effectors, termed SMAD proteins. The activated TGF-β receptor induces phosphorylation of two such proteins, Smad2 and Smad3 (refs 2, 3, , 5, 6), which form hetero-oligomeric complex(es) with Smad4/DPC4 (refs 5, 6, 7, 8, 9, 10) that translocate to the nucleus,,,, where they then regulate transcriptional responses,. However, the mechanisms by which the intracellular signals of TGF-β are… Expand
Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7*
Role of Smads in TGFβ signaling
Transcriptional Regulation by Smads
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
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References

SHOWING 1-10 OF 28 REFERENCES
TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4
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1
2
3
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