Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

  title={Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation},
  author={Tatiana Y. Besschetnova and Elona Kolpakova-Hart and Yinghua Guan and Jing Zhou and Bjorn Reino Olsen and Jagesh V. Shah},
  journal={Current Biology},
The primary cilium acts as a transducer of extracellular stimuli into intracellular signaling [1, 2]. Its regulation, particularly with respect to length, has been defined primarily by genetic experiments and human disease states in which molecular components that are necessary for its proper construction have been mutated or deleted [1]. However, dynamic modulation of cilium length, a phenomenon observed in ciliated protists [3, 4], has not been well-characterized in vertebrates. Here we… CONTINUE READING
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