Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

@article{Besschetnova2010IdentificationOS,
  title={Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation},
  author={Tatiana Y. Besschetnova and Elona Kolpakova-Hart and Yinghua Guan and Jing Zhou and Bjorn Reino Olsen and Jagesh V. Shah},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={182-187}
}
The primary cilium acts as a transducer of extracellular stimuli into intracellular signaling [1, 2]. Its regulation, particularly with respect to length, has been defined primarily by genetic experiments and human disease states in which molecular components that are necessary for its proper construction have been mutated or deleted [1]. However, dynamic modulation of cilium length, a phenomenon observed in ciliated protists [3, 4], has not been well-characterized in vertebrates. Here we… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 107 extracted citations

Primary cilia: Cell and molecular mechanosensors directing whole tissue function.

Seminars in cell & developmental biology • 2017
View 13 Excerpts
Highly Influenced

Factors that influence primary cilium length.

View 6 Excerpts
Highly Influenced

Primary Cilia Deficiency Induces Intracranial Aneurysm

Shock • 2018
View 4 Excerpts
Highly Influenced

Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2014
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Polycystic kidney disease.

Annual review of medicine • 2009
View 5 Excerpts
Highly Influenced

Renal primary cilia lengthen after acute tubular necrosis.

Journal of the American Society of Nephrology : JASN • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…