Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

@inproceedings{Belisle2010IdentificationOS,
  title={Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes},
  author={Jennifer A. Belisle and Sachi Horibata and Gubbels Aa Jennifer and Sarah E Petrie and Arvinder K Kapur and Sabine Andr{\'e} and Hans-Joachim Gabius and Claudine Rancourt and J P Connor and James C Paulson and Manish S Patankar},
  booktitle={Molecular Cancer},
  year={2010}
}
BackgroundMUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates peritoneal metastasis of ovarian tumors. Both sMUC16 and csMUC16 also protect cancer cells from cytotoxic responses of natural killer (NK) cells. In a previous study we… CONTINUE READING

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