Identification of Shc docking site on Ret tyrosine kinase

  title={Identification of Shc docking site on Ret tyrosine kinase},
  author={Elena Arighi and Luisella Alberti and Francesca Torriti and Simona Ghizzoni and Maria Grazia Rizzetti and Giuliana Pelicci and Barbara Pasini and Italia Bongarzone and Claudia Piutti and Marco Alessandro Pierotti and Maria Grazia Borrello},
The RET proto-oncogene encodes two isoforms of a receptor type tyrosine kinase which plays a role in neural crest and kidney development. Distinct germ-line mutations of RET have been associated with the inherited cancer syndromes MEN2A, MEN2B and FMTC as well as with the congenital disorder Hirschsprung disease (HSCR), whereas somatic rearrangements (RET/PTCs) have been frequently detected in the papillary thyroid carcinoma. Despite these findings, suggesting a relevant role for RET product in… CONTINUE READING