Identification of Sestrin3 Involved in the In vitro Resistance of Colorectal Cancer Cells to Irinotecan

@inproceedings{Choi2015IdentificationOS,
  title={Identification of Sestrin3 Involved in the In vitro Resistance of Colorectal Cancer Cells to Irinotecan},
  author={Seung Ho Choi and Hye Kyung Hong and Yong B. Cho and Woo Yong Lee and Hae Yong Yoo},
  booktitle={PloS one},
  year={2015}
}
Irinotecan, an analogue of camptothecin, is frequently used as a single agent or in combination with other anticancer drugs for the treatment of colorectal cancer. However, the drug resistance of tumors is a major obstacle to successful cancer treatment. In this study, we established that cells acquire chronic resistance to irinotecan. We profiled their differential gene expression using microarray. After gene ontology (GO) and KEGG pathway analysis of the microarray data, we specifically… CONTINUE READING
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  • PMID:
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