Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

@article{Acton1996IdentificationOS,
  title={Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor},
  author={Susan L. Acton and Attilio Rigotti and Katherine T. Landschulz and Shangzhe Xu and Helen H. Hobbs and Monty Krieger},
  journal={Science},
  year={1996},
  volume={271},
  pages={518 - 520}
}
High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL… 
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2,295 Citations

The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism

The HDL receptor scavenger receptor class B type I (SR-BI), which mediates selective HDL cholesterol uptake, plays a role in murine HDL metabolism, reverse cholesterol transport and whole-body…

Negatively cooperative binding of high-density lipoprotein to the HDL receptor SR-BI.

TLDR
Application of the "infinite dilution" dissociation rate method established that the binding of (125)I-HDL to SR-BI at 4 °C exhibits negative cooperativity, which should be taken into account when interpreting the results of experiments that explore the mechanism by whichSR-BI mediates ligand binding, lipid transport, and cell signaling.

A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways.

Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis

TLDR
The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described and the importance of SR-BI in overall HDL cholesterol metabolism and its antiatherogenic activity in vivo has been definitively established by SR- BI gene manipulation in mice.

SR-BI and cholesterol uptake into steroidogenic cells

Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes

TLDR
It is suggested that SR-BI deficiency promoted ApoM expression, but the increased ApiM might be independent from HDL-mediated cholesterol uptake in hepatocytes, as well as up-regulate ApaM expression in serum-containing medium.

Influence of the HDL receptor SR-BI on atherosclerosis.

TLDR
The scavenger receptor class B, type I (SR-BI) is an HDL receptor that mediates selective cholesterol uptake from HDL to cells that protects against atherosclerosis in mice and may become an attractive target for therapeutic intervention in humans.

Transport of Lipids from High and Low Density Lipoproteins via Scavenger Receptor-BI*

TLDR
Data indicate that SR-BI is able to exchange cholesterol rapidly between lipoproteins and cell membranes and can mediate the uptake of cholesteryl esters from both classes of lipoprotein, but HDL was a more effective donor.

Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake.

SR-BI-mediated High Density Lipoprotein (HDL) Endocytosis Leads to HDL Resecretion Facilitating Cholesterol Efflux*

TLDR
Evidence that HDL retroendocytosis represents one of the pathways for cholesterol efflux is presented, as well as three physiologically relevant cell systems, including the liver cell line HepG2, the adrenal cell line Y1BS1, and phorbol myristate acetate-differentiated THP-1 cells as a model for macrophages.
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References

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TLDR
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TLDR
The experiments show that high‐density lipoprotein3 cholesteryl esters selectively taken up by hepatocytes are hydrolyzed independently from the classical lysosomal catabolic pathway, showing a net mass delivery of high‐ density lipop protein cholesterol esters to hepatocytes.

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TLDR
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