Identification of SUMO target proteins by quantitative proteomics.

@article{Andersen2009IdentificationOS,
  title={Identification of SUMO target proteins by quantitative proteomics.},
  author={Jens Skorstengaard Andersen and Ivan Matic and Alfred C O Vertegaal},
  journal={Methods in molecular biology},
  year={2009},
  volume={497},
  pages={
          19-31
        }
}
The identification of target proteins for small ubiquitin-like modifiers (SUMOs) is a critical step towards a detailed understanding of the cellular functions of SUMOs. Substrate protein identification for SUMOs is hampered by the low abundance of SUMO targets, the finding that only a small fraction of these target proteins is sumoylated, and the high activity of deconjugating enzymes. Quantitative proteomics is a powerful tool to overcome these challenges, because it allows discrimination… CONTINUE READING
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