Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway

@article{Anazawa2004IdentificationOS,
  title={Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway},
  author={Yoshio Anazawa and Hirofumi Arakawa and Hidewaki Nakagawa and Yusuke Nakamura},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={7621-7627}
}
A mutant version of p53 (p53-121F), in which phenylalanine replaces the 121st serine residue, can induce apoptosis more effectively than wild-type p53 (wt-p53). In view of this observation, we considered that one or more apoptosis-related p53-target genes might be preferentially induced by p53-121F. We carried out cDNA microarray analysis to identify such genes, using mRNAs isolated from LS174T colon-cancer cells infected by adenovirus vectors containing either p53-121F (Ad-p53-121F) or wt-p53… CONTINUE READING

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