Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.

@article{Ren2005IdentificationOS,
  title={Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.},
  author={Decheng Ren and M. Li and Chaojun Duan and L. Rui},
  journal={Cell metabolism},
  year={2005},
  volume={2 2},
  pages={
          95-104
        }
}
  • Decheng Ren, M. Li, +1 author L. Rui
  • Published 2005
  • Biology, Medicine
  • Cell metabolism
  • Leptin regulates energy balance and body weight by activating its receptor LEPRb and multiple downstream signaling pathways, including the STAT3 and the IRS2/PI 3-kinase pathways, in the hypothalamus. Leptin stimulates activation of LEPRb-associated JAK2, which initiates cell signaling. Here we identified SH2-B, a JAK2-interacting protein, as a key regulator of leptin sensitivity, energy balance, and body weight. SH2-B homozygous null mice were severely hyperphagic and obese and developed a… CONTINUE READING
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    References

    SHOWING 1-10 OF 46 REFERENCES
    Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.
    • 488
    PTP1B regulates leptin signal transduction in vivo.
    • 704
    Essential Role of STAT3 in Body Weight and Glucose Homeostasis
    • 138
    • PDF