Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.

@article{Ren2005IdentificationOS,
  title={Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.},
  author={Decheng Ren and Minghua Li and Chaojun Duan and Liangyou Rui},
  journal={Cell metabolism},
  year={2005},
  volume={2 2},
  pages={
          95-104
        }
}
Leptin regulates energy balance and body weight by activating its receptor LEPRb and multiple downstream signaling pathways, including the STAT3 and the IRS2/PI 3-kinase pathways, in the hypothalamus. Leptin stimulates activation of LEPRb-associated JAK2, which initiates cell signaling. Here we identified SH2-B, a JAK2-interacting protein, as a key regulator of leptin sensitivity, energy balance, and body weight. SH2-B homozygous null mice were severely hyperphagic and obese and developed a… CONTINUE READING

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