Identification of RegIV as a Novel GLI1 Target Gene in Human Pancreatic Cancer

  title={Identification of RegIV as a Novel GLI1 Target Gene in Human Pancreatic Cancer},
  author={Feng Wang and Ling Xu and Chuanyong Guo and Aiwu Ke and Guoyong Hu and Xuanfu Xu and Wenhui Mo and Lijuan Yang and Yinshi Huang and Shanshan He and Xing-peng Wang},
  booktitle={PloS one},
BACKGROUND AND AIMS GLI1 is the key transcriptional factor in the Hedgehog signaling pathway in pancreatic cancer. RegIV is associated with regeneration, and cell growth, survival, adhesion and resistance to apoptosis. We aimed to study RegIV expression in pancreatic cancer and its relationship to GLI1. METHODS GLI1 and RegIV expression were evaluated in tumor tissue and adjacent normal tissues of pancreatic cancer patients and 5 pancreatic cancer cell lines by qRT-PCR, Western blot, and… CONTINUE READING
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