Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

  title={Identification of RPS14 as a 5q- syndrome gene by RNA interference screen},
  author={Benjamin L. Ebert and Jennifer L. Pretz and Jocelyn Bosco and Cindy Y. Chang and Pablo Tamayo and Naomi Bruce Galili and Azra Raza and David E Root and Eyal C. Attar and Steven Robert Ellis and Todd R. Golub},
Somatic chromosomal deletions in cancer are thought to indicate the location of tumour suppressor genes, by which a complete loss of gene function occurs through biallelic deletion, point mutation or epigenetic silencing, thus fulfilling Knudson’s two-hit hypothesis. In many recurrent deletions, however, such biallelic inactivation has not been found. One prominent example is the 5q- syndrome, a subtype of myelodysplastic syndrome characterized by a defect in erythroid differentiation. Here we… CONTINUE READING
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