Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target.

@article{Ito2006IdentificationOR,
  title={Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target.},
  author={Hirotaka Ito and Shin-ichi Funahashi and Naoko Yamauchi and Junji Shibahara and Yutaka Midorikawa and Shigeto Kawai and Yasuko Kinoshita and Akira Watanabe and Yoshitaka Hippo and Toshihiko Ohtomo and Hiroko Iwanari and Atsushi Nakajima and Masatoshi Makuuchi and Masashi Fukayama and Yuichi Hirata and Takao Hamakubo and Tatsuhiko Kodama and Masayuki Tsuchiya and Hiroyuki Aburatani},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 11 Pt 1},
  pages={3257-64}
}
PURPOSE Hepatocellular carcinoma is the most common primary malignancy of the liver and accounts for as many as one million deaths annually worldwide. The present study was done to identify new transmembrane molecules for antibody therapy in hepatocellular carcinoma. EXPERIMENTAL DESIGN Gene expression profiles of pooled total RNA from three tissues each of moderately differentiated and poorly differentiated hepatocellular carcinoma were compared with those of normal liver, noncancerous liver… CONTINUE READING