Identification of RIP1 kinase as a specific cellular target of necrostatins.

@article{Degterev2008IdentificationOR,
  title={Identification of RIP1 kinase as a specific cellular target of necrostatins.},
  author={A. Degterev and J. Hitomi and Megan Germscheid and Irene L. Ch’en and O. Korkina and Xin-Chen Teng and Derek W. Abbott and G. Cuny and C. Yuan and G. Wagner and S. Hedrick and S. Gerber and A. Lugovskoy and J. Yuan},
  journal={Nature chemical biology},
  year={2008},
  volume={4 5},
  pages={
          313-21
        }
}
Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented. Although it occurs under regulated conditions, necroptotic cell death is characterized by the same morphological features as unregulated necrotic death. Here we report that necrostatin-1, a previously identified small-molecule inhibitor of necroptosis, is a selective allosteric… Expand
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