Identification of RHD alleles with the potential of anti‐D immunization among seemingly D− blood donors in Upper Austria

@article{Polin2009IdentificationOR,
  title={Identification of RHD alleles with the potential of anti‐D immunization among seemingly D− blood donors in Upper Austria},
  author={Helene Polin and Martin Danzer and Waltraud Gaszner and Doris Broda and Maryse St‐Louis and Johannes Pr{\"o}ll and Katja Hofer and Christian Gabriel},
  journal={Transfusion},
  year={2009},
  volume={49}
}
BACKGROUND: Aberrant RHD alleles leading to a reduced expression of D antigen on the red blood cell (RBC) surface may be mistyped as D− by serology. To quantify the occurrence of weak D, DEL, and D+/− chimera among apparent D− first‐time blood donors, polymerase chain reaction (PCR) screening was implemented as a routine service. 

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...

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TLDR
The least expressed D variants collectively called DEL are serologically detectable only by adsorption‐elution techniques, with so far only poorly defined antigenic properties.

Partial D, weak D types, and novel RHD alleles among 33,864 multiethnic patients: implications for anti‐D alloimmunization and prevention

BACKGROUND: The D antigen includes category D, partial D, and weak D types, which are important because anti‐D alloimmunization can occur in some but not all persons that express a variant RHD

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
In this issue of TRANSFUSION, Polin and colleagues report their approach to molecular testing for RHD, which characterized RHD alleles in 201 samples in which the RBCs were weakly reactive with anti-D and screened samples from 2427 D– donors for the presence of the RHD gene to identify any with low levels of D not detected by serologic testing.

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TLDR
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