Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina

@article{Suzuki2000IdentificationOR,
  title={Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina},
  author={Ryoko Suzuki and Takafumi Shintani and Hiraki Sakuta and Akira Kato and Takeshi Ohkawara and Noriko Osumi and Masaharu Noda},
  journal={Mechanisms of Development},
  year={2000},
  volume={98},
  pages={37-50}
}
In the developing retina, a retinoic acid (RA) gradient along the dorso-ventral axis is believed to be a prerequisite for the establishment of dorso-ventral asymmetry. This RA gradient is thought to result from the asymmetrical distribution of RA-generating aldehyde dehydrogenases along the dorso-ventral axis. Here, we identified a novel aldehyde dehydrogenase specifically expressed in the chick ventral retina, using restriction landmark cDNA scanning (RLCS). Since this molecule showed… CONTINUE READING
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