Identification of Proteinaceous Material in the Bone of the Dinosaur Iguanodon

  title={Identification of Proteinaceous Material in the Bone of the Dinosaur Iguanodon},
  author={Graham Embery and Angela C. Milner and Rachel J Waddington and Rachel C. Hall and M S Langley and Anna M Milan},
  journal={Connective Tissue Research},
  pages={41 - 46}
This study has directed attention at the search for bone-related proteins in an extract of demineralized rib bone of the 120 mya Iguanodon . The inner compact bone was demineralized and the GuCl extract resolved into 11 fractions using anion exchange chromatography, which all contained silver-reactive proteins with various amino acid profiles. Two specific fractions, iv and xi, revealed characteristics typical of contemporary phosphoproteins and proteoglycans, respectively. Fraction iv, 43-57… 
Empirical Evaluation of Bone Extraction Protocols
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Abstract The recent discovery of preserved cells and soft tissues in certain dinosaur bones seems incompatible with an age of millions of years, given the expectation that cells and soft tissues
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Ancient bone collagen retains valuable information. Radiocarbon dating, thermal dating, species identification, cladistics analyses, and paleodietary reconstruction efforts all use bone collagen from
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The Isolation and Detection of Non-Collagenous Proteins from the Compact Bone of the Dinosaur Iguanodon
The isolation of guanidinium chloride extractable protein from deminer-alised bone extracts obtained from the 125–130 mya dinosaur Iguanodon represents the first electro-phoretically defined proteins isolated from dinosaur tissues and suggests the presence of proteoglycans.
Proteins in the fossil bone of the dinosaur, seismosaurus
Proteins have been successfully extracted from the fossil vertebra of a 150-million-year-old sauropod dinosaur recently excavated from the Morrison Formation of New Mexico to provide useful knowledge concerning the evolution of skeletal molecules and the fossilization process.
Characterization of the major non-collagenous proteins of chicken bone: identification of a novel 60 kDa non-collagenous phosphoprotein.
A novel approximately 60 kDa protein was identified with a unique N-terminal amino acid sequence and several internal amino acid sequences and it was demonstrated that the avian form of this protein is more than 80% conserved for all the peptides sequenced in this study.
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Preservation of OC in fossil bones appears to be strongly dependent on the burial history and not simply on age, and is a first step toward a molecular phylogeny of the dinosaurs.
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Our claim, published in this journal, for successful immunodetection of the protein osteocalcin in dinosaur bone has been challenged on the grounds that the findings are inconsistent with the
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Histochemical demonstration of DNA in osteocytes from dinosaur bones.
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    Folia histochemica et cytobiologica
  • 1995
It is suggested that an intact cell sheath enabled the preservation of DNA, though it simultaneously prevented the penetration of reagents and dyes into the cells in unsectioned material, in osteocytes with porous sheaths.
Multiple forms of rat dentin phosphoproteins.