Identification of Protein Fold Topology Shared between Different Folds Inhibited by Natural Products

  title={Identification of Protein Fold Topology Shared between Different Folds Inhibited by Natural Products},
  author={Bernadette M McArdle and Ronald J. Quinn},
Natural products have withstood the test of time as therapeutics, but new lead‐generation strategies have focussed away from natural products. A new approach that uses natural‐product recognition to drive an understanding of biological space might provide an impetus for renewed focus on natural‐product starting points. Protein fold topology (PFT) has been shown to be an underlying factor for natural‐product recognition. An investigation of natural product inhibitors of the Zincin‐like fold has… 

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