Identification of Pivotal Genes and Pathways in Osteoarthritic Degenerative Meniscal Lesions via Bioinformatics Analysis of the GSE52042 Dataset

@article{Huan2019IdentificationOP,
  title={Identification of Pivotal Genes and Pathways in Osteoarthritic Degenerative Meniscal Lesions via Bioinformatics Analysis of the GSE52042 Dataset},
  author={Xu Huan and Ying Jin-he and Zheng Rongzong},
  journal={Medical Science Monitor : International Medical Journal of Experimental and Clinical Research},
  year={2019},
  volume={25},
  pages={8891 - 8904}
}
  • Xu Huan, Ying Jin-he, Zheng Rongzong
  • Published 2019
  • Biology, Medicine
  • Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background To better understand the process of osteoarthritic degenerative meniscal lesions (DMLs) formation, this study analyzed the dataset GSE52042 using bioinformatics methods to identify the pivotal genes and pathways related to osteoarthritic DMLs. Material/Methods The GSE52042 dataset, comprising diseased meniscus samples and healthier meniscus samples, was downloaded and the differentially-expressed genes (DEGs) were extracted. The reactome pathways assessment and functional analysis… Expand
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References

SHOWING 1-10 OF 78 REFERENCES
Microarray analysis of the molecular mechanisms associated with age and body mass index in human meniscal injury
  • 2
  • PDF
Comparative Analysis of Gene Expression between Cartilage and Menisci in Early‐Phase Osteoarthritis of the Knee—An Animal Model Study
  • 6
Inflammatory molecules produced by meniscus and synovium in early and end‐stage osteoarthritis: a coculture study
  • 20
  • PDF
Transcriptome comparison of meniscus from patients with and without osteoarthritis.
  • 21
Analysis of meniscal degeneration and meniscal gene expression
  • 59
  • PDF
Screening of Hub Genes and Pathways in Colorectal Cancer with Microarray Technology
  • 24
Meniscal degeneration in human knee osteoarthritis: in situ hybridization and immunohistochemistry study
  • 10
...
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2
3
4
5
...