Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons.

@article{ToledoAral1997IdentificationOP,
  title={Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons.},
  author={Juan Jos{\'e} Toledo-Aral and Brenda L. Moss and Z. J. He and Adam G. Koszowski and T D Whisenand and Simon Rock Levinson and Jayanthi J. Wolf and Inmaculada Silos-Santiago and Simon Halegoua and Gail Mandel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 4},
  pages={1527-32}
}
Membrane excitability in different tissues is due, in large part, to the selective expression of distinct genes encoding the voltage-dependent sodium channel. Although the predominant sodium channels in brain, skeletal muscle, and cardiac muscle have been identified, the major sodium channel types responsible for excitability within the peripheral nervous system have remained elusive. We now describe the deduced primary structure of a sodium channel, peripheral nerve type 1 (PN1), which is… CONTINUE READING
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