Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.

@article{Nomura1998IdentificationOP,
  title={Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.},
  author={Hideki Nomura and Alberto E. Turco and Yuan Chao Pei and Luba V Kalaydjieva and Tina Schiavello and Stanislawa Weremowicz and Weizhen Ji and Cynthia C Morton and Miriam H. Meisler and S. T. Reeders and Juhua Zhou},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 40},
  pages={25967-73}
}
Polycystin-1 and polycystin-2 are the products of PKD1 and PKD2, genes that are mutated in most cases of autosomal dominant polycystic kidney disease. Polycystin-2 shares approximately 46% homology with pore-forming domains of a number of cation channels. It has been suggested that polycystin-2 may function as a subunit of an ion channel whose activity is regulated by polycystin-1. Here we report the identification of a human gene, PKDL, which encodes a new member of the polycystin protein… CONTINUE READING
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