Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen.

@article{Rahrmann2009IdentificationOP,
  title={Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen.},
  author={Eric P. Rahrmann and Lara S. Collier and Todd P. Knutson and Meghan E Doyal and Sheri L. Kuslak and Laura E. Green and Rita L. Malinowski and Laura S Roethe and Keiko Akagi and Michelle A. Waknitz and Wei Huang and David A. Largaespada and Paul C. Marker},
  journal={Cancer research},
  year={2009},
  volume={69 10},
  pages={4388-97}
}
Retroviral and transposon-based mutagenesis screens in mice have been useful for identifying candidate cancer genes for some tumor types. However, many of the organs that exhibit the highest cancer rates in humans, including the prostate, have not previously been amenable to these approaches. This study shows for the first time that the Sleeping Beauty transposon system can be used to identify candidate prostate cancer genes in mice. Somatic mobilization of a mutagenic transposon resulted in… CONTINUE READING

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Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are Cancer

  • W Richter, SL Jin, M. Conti
  • Research Cancer Res
  • 2009
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