Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

@article{Imai2008IdentificationOO,
  title={Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury},
  author={Yumiko Imai and Keiji Kuba and Graham Greg Neely and Rubina Yaghubian-Malhami and Thomas Perkmann and G. C. van Loo and Maria A. Ermolaeva and Ruud J. Veldhuizen and Y. H. Connie Leung and Hongliang Wang and Haolin Liu and Yang Sun and Manolis Pasparakis and Manfred Kopf and Christin Mech and Sina Bavari and Joseph Sriyal Malik Peiris and Arthur S Slutsky and Shizuo Akira and Malin Hultqvist and Rikard Holmdahl and John Nicholls and Chengyu Jiang and Christoph J. Binder and Josef M. Penninger},
  journal={Cell},
  year={2008},
  volume={133},
  pages={235-249}
}
Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of… CONTINUE READING