Identification of OmpT as the protease that hydrolyzes the antimicrobial peptide protamine before it enters growing cells of Escherichia coli.

Abstract

The influence of extracytoplasmic proteases on the resistance of Escherichia coli to the antimicrobial peptide protamine was investigated by testing strains with deletions in the protease genes degP, ptr, and ompT. Only DeltaompT strains were hypersusceptible to protamine. This effect was abolished by plasmids carrying ompT. Both at low and at high Mg2… (More)

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@article{Stumpe1998IdentificationOO, title={Identification of OmpT as the protease that hydrolyzes the antimicrobial peptide protamine before it enters growing cells of Escherichia coli.}, author={Stefan Stumpe and Roland M Schmid and Diane L Stephens and George D. Georgiou and Evert P. Bakker}, journal={Journal of bacteriology}, year={1998}, volume={180 15}, pages={4002-6} }