Identification of Ny-Eso-1 Epitopes Presented by Human Histocompatibility Antigen (Hla)-Drb4*0101–0103 and Recognized by Cd4+T Lymphocytes of Patients with Ny-Eso-1–Expressing Melanoma

@article{Jger2000IdentificationON,
  title={Identification of Ny-Eso-1 Epitopes Presented by Human Histocompatibility Antigen (Hla)-Drb4*0101–0103 and Recognized by Cd4+T Lymphocytes of Patients with Ny-Eso-1–Expressing Melanoma},
  author={Elke J{\"a}ger and Dirk Jaeger and Julia Karbach and Y T Chen and Gerd Ritter and Yasuhiro Nagata and Sacha Gnjatic and Elisabeth Stockert and Michael Arand and Lloyd J. Old and Alexander Knuth},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={625 - 630}
}
NY-ESO-1 is a member of the cancer-testis family of tumor antigens that elicits strong humoral and cellular immune responses in patients with NY-ESO-1-expressing cancers. Since CD4(+) T lymphocytes play a critical role in generating antigen-specific cytotoxic T lymphocyte and antibody responses, we searched for NY-ESO-1 epitopes presented by histocompatibility leukocyte antigen (HLA) class II molecules. Autologous monocyte-derived dendritic cells of cancer patients were incubated with… CONTINUE READING
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