Identification of Novel Genes Coding for Small Expressed RNAs

@article{LagosQuintana2001IdentificationON,
  title={Identification of Novel Genes Coding for Small Expressed RNAs},
  author={M. Lagos-Quintana and R. Rauhut and W. Lendeckel and T. Tuschl},
  journal={Science},
  year={2001},
  volume={294},
  pages={853 - 858}
}
  • M. Lagos-Quintana, R. Rauhut, +1 author T. Tuschl
  • Published 2001
  • Biology, Medicine
  • Science
  • In Caenorhabditis elegans, lin-4and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that… CONTINUE READING

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