Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.

  title={Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.},
  author={Md. Faiz Ahmad and Sarah E Huff and John J. Pink and Intekhab Alam and Andrew X Zhang and Kay Perry and Michael J. Harris and Tessianna A Misko and Suheel K Porwal and Nancy Oleinick and Masaru Miyagi and Rajesh Viswanathan and Chris Godfrey Dealwis},
  journal={Journal of medicinal chemistry},
  volume={58 24},
Ribonucleotide reductase (RR) catalyzes the rate-limiting step of dNTP synthesis and is an established cancer target. Drugs targeting RR are mainly nucleoside in nature. In this study, we sought to identify non-nucleoside small-molecule inhibitors of RR. Using virtual screening, binding affinity, inhibition, and cell toxicity, we have discovered a class of small molecules that alter the equilibrium of inactive hexamers of RR, leading to its inhibition. Several unique chemical categories… CONTINUE READING
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