Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.

@article{Chen1998IdentificationON,
  title={Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.},
  author={M S Chen and Hua She and Edward M. Davis and Carol Mason Spicer and Leung Kim and Ruihua Ren and Michelle M Le Beau and Wei Li},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 39},
  pages={25171-8}
}
Already a dozen molecules share binding to the Src homology (SH) 3 domains of human Nck, an SH3-SH3-SH3-SH2 adapter protein. We reason that there may be multiple gene members of Nck to accommodate the large binding repertoires. Here we report identification of novel human and mouse Nck genes and rename them as the Nckalpha and Nckbeta genes (including the human Nckalpha, human Nckbeta, mouse Nckalpha, and mouse Nckbeta genes). Nckalpha and Nckbeta share 68% amino acid identity, whereas the two… CONTINUE READING
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