Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.

@article{Leonard2017IdentificationON,
  title={Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.},
  author={John D Leonard and Dana C Gilmore and Thamotharampillai Dileepan and Wioletta I Nawrocka and Jaime L Chao and Mary H Schoenbach and Marc K Jenkins and Erin J. Adams and Peter A. Savage},
  journal={Immunity},
  year={2017},
  volume={47 1},
  pages={
          107-117.e8
        }
}
Regulatory T (Treg) cells expressing the transcription factor Foxp3 are critical for the prevention of autoimmunity and the suppression of anti-tumor immunity. The major self-antigens recognized by Treg cells remain undefined, representing a substantial barrier to the understanding of immune regulation. Here, we have identified natural Treg cell ligands in mice. We found that two recurrent Treg cell clones, one prevalent in prostate tumors and the other associated with prostatic autoimmune… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 35 times over the past 90 days. VIEW TWEETS
5 Citations
60 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Similar Papers

Loading similar papers…