Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance

@article{Lu2013IdentificationON,
  title={Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance},
  author={B. Lu and I. Al‐Ramahi and A. Valencia and Qiong-ling Wang and Frada Berenshteyn and Haidi Yang and Tatiana Gallego-Flores and Salah Ichcho and Arnaud Lacoste and M. Hild and M. DiFiglia and J. Botas and J. Palacino},
  journal={Nature Neuroscience},
  year={2013},
  volume={16},
  pages={562-570}
}
Huntington's disease is caused by expanded CAG repeats in HTT, conferring toxic gain of function on mutant HTT (mHTT) protein. Reducing mHTT amounts is postulated as a strategy for therapeutic intervention. We conducted genome-wide RNA interference screens for genes modifying mHTT abundance and identified 13 hits. We tested 10 in vivo in a Drosophila melanogaster Huntington's disease model, and 6 exhibited activity consistent with the in vitro screening results. Among these, negative regulator… Expand
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