Identification of NOG as a specific breast cancer bone metastasis-supporting gene.

  title={Identification of NOG as a specific breast cancer bone metastasis-supporting gene.},
  author={Maria Jes{\'u}s Tarragona and Milica Pavlovic and Anna Arnal-Estap{\'e} and Jelena Urosevic and M{\'o}nica A. {\'A}lvarez Morales and Marc Guiu and Evarist Planet and Eva Gonz{\'a}lez-Su{\'a}rez and Roger R Gomis},
  journal={The Journal of biological chemistry},
  volume={287 25},
Metastasis requires numerous biological functions that jointly provide tumor cells from a primary site to seed and colonize a distant organ. Some of these activities are selected for in the primary site, whereas others are acquired at the metastatic niche. We provide molecular evidence showing that the BMP inhibitor, NOG, provides metastatic breast cancer cells with the ability to colonize the bone. NOG expression is acquired during the late events of metastasis, once cells have departed from… CONTINUE READING
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