Identification of NAD+ capped mRNAs in Saccharomyces cerevisiae.

  title={Identification of NAD+ capped mRNAs in Saccharomyces cerevisiae.},
  author={Robert W. Walters and Tyler Matheny and Laura S. Mizoue and Bhalchandra S. Rao and Denise Muhlrad and Roy Parker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={114 3},
RNAs besides tRNA and rRNA contain chemical modifications, including the recently described 5' nicotinamide-adenine dinucleotide (NAD+) RNA in bacteria. Whether 5' NAD-RNA exists in eukaryotes remains unknown. We demonstrate that 5' NAD-RNA is found on subsets of nuclear and mitochondrial encoded mRNAs in Saccharomyces cerevisiae NAD-mRNA appears to be produced cotranscriptionally because NAD-RNA is also found on pre-mRNAs, and only on mitochondrial transcripts that are not 5' end processed… CONTINUE READING
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