Identification of N4-(2-propenal)spermidine as a major reaction product of malondialdehyde and spermidine.

The reactivity of malondialdehyde(MDA) with spermidine at the physiological pH was considerably higher than that with putrescine, glycine, lysine, methylamine or dimethylamine, and the major reaction product of MDA-spermidine adduct was identified as N4-(2-propenal)spermidine.