Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase.

Abstract

Sonic Hedgehog (Shh) is a secreted morphogen that regulates embryonic development. After removal of the signal peptide, Shh is processed to the mature, active form through autocleavage and a series of lipid modifications, including the attachment of palmitate. Covalent attachment of palmitate to the N-terminal cysteine of Shh is catalyzed by Hedgehog… (More)
DOI: 10.1074/jbc.M112.426833

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@article{Hardy2012IdentificationON, title={Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase.}, author={Rayshonda Y Hardy and Marilyn D. Resh}, journal={The Journal of biological chemistry}, year={2012}, volume={287 51}, pages={42881-9} }